Abstract
The GH inbred Wistar rat possesses reduced numbers of sympathetic motor neurons. In the present study, we report that substance P (SP) concentrations in superior cervical ganglion, spinal cord, iris and trachea of GH rats are about two-fold those in normal rats, and that SP-containing sensory neuron numbers are elevated in GH rats. These data suggest increased perinatal survival of SP neurons in the GH strain, due to reduced competition by sympathetic neurons for limited amounts of nerve growth factor. By contrast with the situation in iris and trachea, we found no difference between GH and normal rats in SP content of ear skin, atrium or stomach. This accords with previous findings that only some SP sensory neurons are responsive to nerve growth factor.
Published Version
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