Abstract
The effect of increasing caloric intake on blood glucose regulation was investigated in nine mild, adult-onset diabetic patients treated by diet with or without oral hriypoglycemic agents. During the initial week of hospitalization, patients received their previously prescribed diet and oral hypoglycemic agents. Blood sugar and plasma insulin was determined before each meal, and 24-h glycosuria was quantitated. The diet was then increased by 500 cal/day each week until the basal calories doubled or the patient could not consume the additional food. The percentage distribution among carbohydrate, protein, and fat and feedings during the day were kept constant. In four of the patients, no significant increase in blood glucose was observed despite the doubling of caloric intake. In an additional four patients, only one of the four blood glucose determinations was significantly increased as a consequence of the increased calories. The plasma insulin values in six of these patients demonstrated significant inc...
Published Version
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