Abstract
BackgroundHigh sensitivity C-reactive protein (Hs-CRP) and adiponectin (APN) are two critical cytokines and exert inverse effects on atherosclerosis initiation and progression. The purpose of our study was to investigate the value of Hs-CRP and ANP ratio (Hs-CRP/APN ratio) on evaluating atherosclerosis progression.MethodOne hundred sixty consecutive participants underwent carotid intima-media thickness (CIMT) measured by ultrasound were enrolled and drawn fasting blood samples for plasma levels Hs-CRP and APN, serum levels of lipid profiles and fasting blood glucose evaluation. Other anthropometrics and clinical status were collected by questionnaire. All participants were divided into 4 groups according to the baseline Hs-CRP/APN ratio and underwent CIMT measurement every 6 months. CIMT increment and composite cardiovascular endpoints were compared after 24 months’ follow-up.ResultsAt baseline, body mass index (BMI), smoking, diabetic mellitus, usage of statins, Hs-CRP and APN independently correlated with Hs-CRP/APN ratio as analyzed by spearman rank correlation. Smoking, serum level of LDL-C, plasma level of Hs-CRP and Hs-CRP/APN ratio were positively correlated with CIMT while usage of statins and plasma level of APN were negatively correlated with CIMT as analyzed by multiple linear regression analysis. After 24 months’ follow-up, the progression of CIMT was the most prominent in the fourth quartile of baseline Hs-CRP/APN ratio. In addition, the incidence of composite cardiovascular endpoint was also higher in the fourth quartile as compared to the other 3 lower quartiles.ConclusionHs-CRP/APN ratio was a useful predictor to discriminate subjects who were at increased risk of atherosclerosis progression.
Highlights
In the past decades, accumulating evidence from basic and clinical studies consistently demonstrate that inflammation plays pivotal and complicated roles in the initiation and progression of atherosclerosis and atherosclerotic cardiovascular diseases [1,2,3]
At baseline, body mass index (BMI), smoking, diabetic mellitus, usage of statins, High sensitivity C-reactive protein (Hs-CRP) and APN independently correlated with Hs-CRP/APN ratio as analyzed by spearman rank correlation
Serum level of low density lipoprotein-cholesterol (LDL-C), plasma level of Hs-CRP and Hs-CRP/APN ratio were positively correlated with Carotid intima-media thickness (CIMT) while usage of statins and plasma level of APN were negatively correlated with CIMT as analyzed by multiple linear regression analysis
Summary
In the past decades, accumulating evidence from basic and clinical studies consistently demonstrate that inflammation plays pivotal and complicated roles in the initiation and progression of atherosclerosis and atherosclerotic cardiovascular diseases [1,2,3]. Increased serum level of inflammatory cytokines portends a higher incidence of cardiovascular events such as myocardial infarction and ischemic stroke [4,5]. Guidelines have recommended that inflammatory cytokines such as high sensitivity C-reactive protein (Hs-CRP) should be integrated into the algorithm of cardiovascular risk evaluation [1,6]. We conducted a pilot study to investigate the relationship between Hs-CRP/APN ratio and CIMT in population without overt cardiovascular diseases, and we consecutively measured CIMT in the follow-up 24 months so as to determine the value of Hs-CRP/APN ratio in predicting CIMT progression and future cardiovascular events. High sensitivity C-reactive protein (Hs-CRP) and adiponectin (APN) are two critical cytokines and exert inverse effects on atherosclerosis initiation and progression. The purpose of our study was to investigate the value of Hs-CRP and ANP ratio (Hs-CRP/APN ratio) on evaluating atherosclerosis progression
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
