Increased glycated albumin and decreased esRAGE concentrations are associated with in-stent restenosis in Chinese diabetic patients

Abstract

Background We investigated the impact of glycated albumin (GA) and endogenous secretory receptor for advanced glycation end products (esRAGE) and RAGE polymorphisms on occurrence of in-stent restenosis (ISR) in Chinese patients with type 2 diabetes. Methods Four hundred nineteen patients with diabetes were divided, based upon the presence or absence of coronary artery disease (CAD) and ISR, into Group I (205 patients without CAD), Group II (128 patients with CAD but without ISR) and Group III (86 patients with ISR). One hundred fifty-two normal subjects were served as controls. Serum concentrations of GA and esRAGE were measured, and RAGE polymorphisms (−374T>A, −429T>C and G82S) were analyzed. Results Serum GA concentration was higher and, in contrast, esRAGE concentration was lower in Group III than in the other groups ( P < 0.05). These two protein concentrations correlated closely with loss index (all P < 0.01), and were independent risk factors for ISR in diabetic patients ( P = 0.01 and P = 0.025, respectively). However, there were no differences in the allele and genotype frequencies in the 3 polymorphisms of RAGE gene between groups. Conclusions Increased GA and decreased esRAGE concentrations, but not −374T>A, −429T>C and Gly82Ser polymorphisms of RAGE gene, are associated with ISR in Chinese patients with type 2 diabetes.