Abstract
Background and Aims: Obstructive sleep apnea (OSA) is associated with increased risk of cardiovascular disease. Resistin is recognized as a potent proinflammatory cytokine that is able to influence atherosclerotic plaque progression through several mechanisms. Resistin facilitates formation of foam cells through upregulation of CD36 scavenger receptor and increased uptake of oxidized low density lipoprotein. Its proinflammatory effects are mainly exerted via adenylate cyclase-associated protein 1 (CAP1). The aim of this study was to investigate if resistin, CAP1 and CD36 mRNA levels in peripheral blood mononuclear cells (PBMCs) are associated with hypercholesterolemia in patients with obstructive sleep apnea.
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