Abstract
5,6-Dihydropyrazolo[1,5- a ]pyrazines prepared via the Ugi reaction involving pyrazole-3-carboxylic convertible tert -butyl isocyanide and subsequent microwave-promoted cyclization, were found to be prone to opening with primary and secondary amines, thereby providing a facile, three-step access to a greater diversity of Ugi-type dipeptoids, some of which cannot be accessed via the Ugi reaction itself.
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