Abstract
Background and aims: The active metabolite of vitamin D3, 1,25-dihydroxyvitamin D3 (1,25D3) inhibits cell growth in numerous tumors as colon, prostate, breast. The role of 1,25-D3 in the development of the hepatocellular carcinoma (HCC) has not yet been established. We aimed to study the mRNA expression of vitamin D inactivating CYP24A1 enzyme in HCC cell lines after 1,25D3 treatment in vitro and also in human HCC tissue samples.
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