Abstract
Abstract Thymidine kinase activity and DNA content were determined in the cerebellum after the administration of diethylstilbestrol (DES) to neonatal female rats. Rats were injected s.c. with either 30 μg DES or vehicle 48 h after birth. DNA and thymidine kinase were measured in the cerebellum at 3, 7, 10, 18, 21, 26, and 60 days of age. Thymidine kinase activity and DNA content in the DES-treated littermates were significantly increased between ages 3 to 21 days and ages 3 to 26 days, respectively. The data suggest diethylstilbestrol-induced relationships between thymidine kinase activity and DNA synthesis during the period of rapid cerebellar development.
Published Version
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