Increased Bioavailability of 11‐Keto‐β‐Boswellic Acid Following Single Oral Dose Frankincense Extract Administration After a Standardized Meal in Healthy Male Volunteers: Modeling and Simulation Considerations for Evaluating Drug Exposures

Abstract

The Journal of Clinical PharmacologyVolume 52, Issue 10 p. 1592-1600 Increased Bioavailability of 11-Keto-β-Boswellic Acid Following Single Oral Dose Frankincense Extract Administration After a Standardized Meal in Healthy Male Volunteers: Modeling and Simulation Considerations for Evaluating Drug Exposures Dr Carsten Skarke MD, Corresponding Author Dr Carsten Skarke MD Institute for Translational Medicine and Therapeutics (ITMAT), Department of Pharmacology, Perelman School of Medicine, University of Pennsylvania, Philadelphia pharmazentrum frankfurt/ZAFES, Institute of Clinical Pharmacology, Johann Wolfgang Goethe-University, Frankfurt/Main, Germany Clinical Research Center Rhine-Main (KSRM)/ZAFES, Johann Wolfgang Goethe-Universität Frankfurt, Frankfurt/Main, Germany Address for correspondence: Carsten Skarke, MD, Institute for Translational Medicine and Therapeutics (ITMAT), Department of Pharmacology, Perelman School of Medicine, University of Pennsylvania, 8036 Maloney Bldg, 3600 Spruce St, Philadelphia, PA 19104, USA; e-mail: cskarke@mail.med.upenn.edu.Search for more papers by this authorDr Karina Kuczka MD, Dr Karina Kuczka MD pharmazentrum frankfurt/ZAFES, Institute of Clinical Pharmacology, Johann Wolfgang Goethe-University, Frankfurt/Main, GermanySearch for more papers by this authorDr Lars Tausch PhD, Dr Lars Tausch PhD Institute of Pharmaceutical Chemistry, Johann Wolfgang Goethe-University Frankfurt, Frankfurt/Main, GermanySearch for more papers by this authorDr Oliver Werz PhD, Dr Oliver Werz PhD Department of Pharmaceutical Analytics, Pharmaceutical Institute, Eberhard-Karls-University Tuebingen, Tuebingen, GermanySearch for more papers by this authorDr Tanja Rossmanith MD, Dr Tanja Rossmanith MD Clinical Research Center Rhine-Main (KSRM)/ZAFES, Johann Wolfgang Goethe-Universität Frankfurt, Frankfurt/Main, GermanySearch for more papers by this authorDr Jeffrey S. Barrett PhD, FCP, Dr Jeffrey S. Barrett PhD, FCP Clinical Pharmacology & Therapeutics Division, Kinetic Modeling and Simulation (KMAS) Core, The Children's Hospital of Philadelphia (CHOP), Philadelphia, PennsylvaniaSearch for more papers by this authorDr Sebastian Harder MD, Dr Sebastian Harder MD pharmazentrum frankfurt/ZAFES, Institute of Clinical Pharmacology, Johann Wolfgang Goethe-University, Frankfurt/Main, GermanySearch for more papers by this authorDr Wolfgang Holtmeier MD, Dr Wolfgang Holtmeier MD Department of Gastroenterology, Medizinische Klinik 1, University Hospital, Frankfurt, GermanySearch for more papers by this authorDr Joachim A. Schwarz MD, Dr Joachim A. Schwarz MD Clinical Pharmacologist, Internist, Consultant, Dreieich, GermanySearch for more papers by this author Dr Carsten Skarke MD, Corresponding Author Dr Carsten Skarke MD Institute for Translational Medicine and Therapeutics (ITMAT), Department of Pharmacology, Perelman School of Medicine, University of Pennsylvania, Philadelphia pharmazentrum frankfurt/ZAFES, Institute of Clinical Pharmacology, Johann Wolfgang Goethe-University, Frankfurt/Main, Germany Clinical Research Center Rhine-Main (KSRM)/ZAFES, Johann Wolfgang Goethe-Universität Frankfurt, Frankfurt/Main, Germany Address for correspondence: Carsten Skarke, MD, Institute for Translational Medicine and Therapeutics (ITMAT), Department of Pharmacology, Perelman School of Medicine, University of Pennsylvania, 8036 Maloney Bldg, 3600 Spruce St, Philadelphia, PA 19104, USA; e-mail: cskarke@mail.med.upenn.edu.Search for more papers by this authorDr Karina Kuczka MD, Dr Karina Kuczka MD pharmazentrum frankfurt/ZAFES, Institute of Clinical Pharmacology, Johann Wolfgang Goethe-University, Frankfurt/Main, GermanySearch for more papers by this authorDr Lars Tausch PhD, Dr Lars Tausch PhD Institute of Pharmaceutical Chemistry, Johann Wolfgang Goethe-University Frankfurt, Frankfurt/Main, GermanySearch for more papers by this authorDr Oliver Werz PhD, Dr Oliver Werz PhD Department of Pharmaceutical Analytics, Pharmaceutical Institute, Eberhard-Karls-University Tuebingen, Tuebingen, GermanySearch for more papers by this authorDr Tanja Rossmanith MD, Dr Tanja Rossmanith MD Clinical Research Center Rhine-Main (KSRM)/ZAFES, Johann Wolfgang Goethe-Universität Frankfurt, Frankfurt/Main, GermanySearch for more papers by this authorDr Jeffrey S. Barrett PhD, FCP, Dr Jeffrey S. Barrett PhD, FCP Clinical Pharmacology & Therapeutics Division, Kinetic Modeling and Simulation (KMAS) Core, The Children's Hospital of Philadelphia (CHOP), Philadelphia, PennsylvaniaSearch for more papers by this authorDr Sebastian Harder MD, Dr Sebastian Harder MD pharmazentrum frankfurt/ZAFES, Institute of Clinical Pharmacology, Johann Wolfgang Goethe-University, Frankfurt/Main, GermanySearch for more papers by this authorDr Wolfgang Holtmeier MD, Dr Wolfgang Holtmeier MD Department of Gastroenterology, Medizinische Klinik 1, University Hospital, Frankfurt, GermanySearch for more papers by this authorDr Joachim A. Schwarz MD, Dr Joachim A. Schwarz MD Clinical Pharmacologist, Internist, Consultant, Dreieich, GermanySearch for more papers by this author First published: 07 March 2013 https://doi.org/10.1177/0091270011422811Citations: 38Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Citing Literature Volume52, Issue10October 2012Pages 1592-1600 RelatedInformation