Abstract
Beta-glucuronidase activity is known to increase in human atherosclerotic arteries. Since beta-glucuronidase is a key marker enzyme for lysosomal activity, it was decided to investigate the activity of other lysosomal enzymes. In intima-media homogenates of human atherosclerotic aortas there was found an increased total activity of cathepsin, suggestive evidence for acid phosphatase, and no change in arylsulfatase. Beta-glucuronidase showed the greatest increase in total activity. Besides showing these changes in total activity, all four enzymes exhibited definitely increased activity in the lysosomal fraction of the atherosclerotic aortas.
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