Abstract
BackgroundA recent report indicated that numbers of Sutterella spp. are elevated in gastrointestinal biopsies taken from children with autism spectrum disorder (ASD). We have recently reported changes in the numbers of some bacteria within the stool of ASD children, and now examine whether numbers of Sutterella spp. and some other mucosa-associated bacteria linked with gastrointestinal disease (Ruminococcus gnavus and Ruminococcus torques) are also altered in the stool of these children.FindingsWe show that numbers of Sutterella spp. are elevated in feces of ASD children relative to controls, and that numbers of R. torques are higher in the children with ASD with a reported functional gastrointestinal disorder than those without such a disorder.ConclusionsWe show further evidence of changes in the gut microbiota of children with ASD and confirm that the abundance of Sutterella spp. is altered in stool.
Highlights
A recent report indicated that numbers of Sutterella spp. are elevated in gastrointestinal biopsies taken from children with autism spectrum disorder (ASD)
Williams et al [5] reported a significantly higher prevalence of Sutterella spp. in biopsies taken from the GI tract of ASD children with GI disturbance compared to controls with GI disturbance
* Correspondence: michael.conlon@csiro.au 2Preventative Health National Research Flagship, CSIRO Animal, Food and Health Sciences, Gate 13, Kintore Avenue, Adelaide, South Australia 5001, Australia Full list of author information is available at the end of the article abundance of S. wadsworthensis in colonic biopsies of adults with inflammatory bowel disease (IBD) was not different from controls, Sutterella appeared to be more prevalent in the human gut than previously reported [10]
Summary
A recent report indicated that numbers of Sutterella spp. are elevated in gastrointestinal biopsies taken from children with autism spectrum disorder (ASD). * Correspondence: michael.conlon@csiro.au 2Preventative Health National Research Flagship, CSIRO Animal, Food and Health Sciences, Gate 13, Kintore Avenue, Adelaide, South Australia 5001, Australia Full list of author information is available at the end of the article abundance of S. wadsworthensis in colonic biopsies of adults with inflammatory bowel disease (IBD) was not different from controls, Sutterella appeared to be more prevalent in the human gut than previously reported [10]. We have carried out further QPCR analyses of samples from that study to examine whether the abundance of Sutterella spp. is altered in the feces of children with ASD relative to controls.
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