Abstract
In the present study, serotonin 2C (5-HT 2C) receptor binding parameters in the brainstem and cerebral cortex were investigated during liver generation after partial hepatectomy (PH) and N-nitrosodiethylamine (NDEA) induced hepatic neoplasia in male Wistar rats. The serotonin content increased significantly ( p < 0.01) in the cerebral cortex after PH and in NDEA induced hepatic neoplasia. Brain stem serotonin content increased significantly ( p < 0.05) after PH and ( p < 0.001) in NDEA induced hepatic neoplasia. The number and affinity of the 5-HT 2C receptors in the crude synaptic membrane preparations of the brain stem showed a significant ( p < 0.001) increase after PH and in NDEA induced hepatic neoplasia. The number and affinity of 5-HT 2C receptors increased significantly ( p < 0.001) in NDEA induced hepatic neoplasia in the crude synaptic membrane preparations of the cerebral cortex. There was a significant ( p < 0.01) increase in plasma norepinephrine in PH and ( p < 0.001) in NDEA induced hepatic neoplasia, indicating sympathetic stimulation. Thus, our results suggest that during active hepatocyte proliferation 5-HT 2C receptor in the brain stem and cerebral cortex are up-regulated which in turn induce hepatocyte proliferation mediated through sympathetic stimulation.
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