Abstract
The influence of UMP on the incorporation of labeled guanosine into the rat hippocampus during an optical discrimination test was examined by using the microautoradiographic method and comparing the findings for trained animals with those for the corresponding active controls. Under learning conditions, an increased incorporation of guanosine was observed. This increase in incorporation was significantly enhanced by simultaneous application of UMP. These results support the hypothesis that the retention-extending effect of UMP is due to an increase in RNA synthesis.
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