Abstract
Background: Increasing number of cancer survivor motivates clinical practitioner to focus on chronic effect of chemotherapy agent, especially those with vascular toxicity effect, which may attenuate the incidence of thrombosis and atherogenesis. Ultrasonography examination on carotid intima media thickness (C-IMT) provides acurate result in evaluating atherosclerotic. The purposes of this research are to find out any structural changes of carotid artery, especially atheroclerosis changes in breast cancer patient after chemoteraphy. Methods: Analytic cross sectional study using a pre post test group design in breast cancer patients. Eligible subjects undergo carotid ultrasonography examination prior to chemoteraphy and after they had completed the 3 cycles of chemoteraphy for the second exam. The examination was perfomed with the same USG machine, high frequency linier transducer (>7mHz) in B-mode under the auspecies of two reputable radiologist consultant. Results: Total patients are 26, mean of age (year) is 47.15 ± 8.11. Most dominant histopathology finding is invasive carcinoma nonspecific type, in 24 patients (92.4%) and the disease stage is in stadium III in 14 patients (53.9%). Mean C-IMT (mm) prior chemotherapy is 0.51 ± 0.06 and after chemotherapy is 0.58 ± 0.05, there is an increase of 0.07 ± 0.06 (p<0.0001). Carotid artery lumen diameter (mm) before chemotherapy is 4.05 ± 0.66 and after chemotherapy is 3.90 ± 0.73, so there is a decrease of 0.16 ± 0.40 (p =0.057). Conclusion: There is a statistically significant increase in intima media thickness of carotid wall of breast cancer patients after chemotherapy, consisted with chemoteraphy induced atherosclerosis.
Highlights
Background: Increasing the number of cancer survivors motivates clinical practitioners to focus on the chronic effect of chemotherapy agents, especially those with vascular toxicity effects, which may attenuate the incidence of thrombosis and atherogenesis
Mean carotid intima-media thickness (C-IMT) prior chemotherapy is 0.51 ± 0.06 and after chemotherapy is 0.58 ± 0.05, there is an increase of 0.07 ± 0.06 (p
We studied an interobserver of Paired test for analysis of C-IMT before and the C-IMT measurement result for conformity after chemotherapy
Summary
The survival of cancer patients is currently therapy, especially chemotherapeutic agents. Increase of Carotid Intima-Media Thickness microvascular disruption that causes cancer patients who underwent chemotherapy. Possible to attack only the cardiovascular Carotid ultrasound examination is done course exclusively It will twice, before and after chemotherapy, on the interfere with the cerebrovascular course. Dysfunction in breast cancer patients receiving Measurement of the carotid intima-media chemotherapy. The author intends to prove mm before the bulb), the bulb (5-10 mm whether there are structural changes in the cranial bulb), and the internal carotid artery carotid arteries, especially atherosclerosis, in (10 mm after carotid branching) at the free breast cancer patients who received plaque part. The mean C-IMT is calculated chemotherapy through measurement and from the mean value of the six points examination of carotid ultrasound.
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