Increase in internetwork functional connectivity in the human brain with attention capture.

Abstract

Attention is often extolled for its selective neural properties. Yet, when powerfully captured by a salient unexpected event, attention can give rise to a broad cascade of systemic effects for evaluating and adaptively responding to the event. Using graph theory analysis combined with fMRI, we show here that the extensive psychophysiological and cognitive changes associated with such attention capture are related to large-scale distributed changes in the brain's functional connectivity. Novel task-irrelevant "oddball" stimuli presented to subjects during the performance of a target-search task triggered an increase in internetwork functional connectivity that degraded the brain's network modularity, thereby facilitating the integration of information. Furthermore, this phenomenon habituated with repeated oddball presentations, mirroring the behavior. These functional network connectivity changes are remarkably consistent with those previously obtained with conscious target perception, thus raising the possibility that large-scale internetwork connectivity changes triggered by attentional capture and awareness rely on common neural network dynamics.NEW & NOTEWORTHY The selective properties of attention have been extensively studied. There are some circumstances in which attention can have widespread and systemic effects, however, such as when it is captured by an unexpected, salient stimulus or event. How are such effects propagated in the human brain? Using graph theory analysis of fMRI data, we show here that salient task-irrelevant events produced a global increase in the functional integration of the brain's neural networks.