Abstract
The effect of feeding a stock diet to which had been added 0.25% of dl-ethionine on liver-reduced glutathione (GSH), glutathione reductase (GR), glucose 6-phosphate dehydrogenase (G-6-PD), and 6-phosphogluconate dehydrogenase (6-PGD) was studied in male and female rats. Liver GSH concentration was consistently increased in rats of both sexes fed ethionine. This effect could not be prevented by methionine, which, in fact, also increased liver GSH, but was reversible by feeding an ethionine-free diet. Cysteine, added to the stock diet in place of ethionine, did not increase hepatic GSH. Activities of the enzymes GR and G-6-PD, but not of 6-PGD, were significantly higher in the livers of the ethionine fed rats. Additional studies indicated that ascorbic acid concentrations in blood, liver, and adrenals were reduced after ethionine feeding.
Published Version
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