Abstract
Total liver phospholipids containing fatty acids of different degrees of unsaturation have been demonstrated by P 32 incorporation studies to be synthesized at different rates (1, 2). Since the individual phospholipid species each have a characteristic fatty acid composition, the addition to the diet of some fatty acids may stimulate the synthesis of some types of phospholipids more than others. The addition of cholesterol to the diet, particularly with unsaturated fat, has been found to decrease the rate of incorporation of P 32 into the liver total phospholipids and to produce marked alterations in liver phospholipid fatty acid composition (2, 3). Of the individual phospholipid classes, mitochondria have been demonstrated to contain and synthesize primarily phosphatidyl choline and phosphatidyl ethanolamine (4). The purpose of the present study was to determine the rates of incorporation of exogenous stearate and oleate into these two phospholipids and to determine the effects and possible mode of action of cholesterol on these incorporation rates.
Published Version
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