Abstract
The major radioactive components found in pig adipose tissue after successive administration of the macrolide antibiotic 14 C-sedecamycin were isolated and chemically identified. Eighty-nine percent of the whole radioactivity in the adipose tissue was extracted into the lipid fraction, and 82% of the lipid radioactivity was recovered in the fatty acid fraction, 92% of which was found in palmitate, oleate, and stearate. No significant radioactivity was found in linoleic acid. These results indicate that some metyl carbons of sedecamycin are incorporated into fatty acids, presumably via the usual pathway of de novo biosynthesis in mammals.
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