Abstract
Abstract [ 14 C]oleic acid was incubated in vitro with atherosclerotic aortas obtained from cholesterol-fed rabbits; following incubation, foam cells and other fractions of the aortic wall were separated and studied. Most of the [ 14 C]oleic acid was incorporated into cholesterol ester in the intima whereas most was incorporated into triglyceride and phospholipid in the media. About 10 % of the oleic acid taken up and incorporated into phospholipid, triglyceride or cholesterol ester in the intima was found in the intact foam cells separated. The specific activity of the oleic acid incorporated into both phospholipid and cholesterol ester in the foam cells was considerably higher than that in the other portions of the arterial wall. The role of the foam cell in the synthesis of lipid in the atherosclerotic arterial wall and the possible pathways involved in such synthesis by foam cells are discussed.
Published Version
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