Abstract
Plain Language SummaryNutritional assessment is often overlooked in hepatocellular carcinoma (HCC) management despite its prognostic value. Geriatric nutritional risk index (GNRI), an objective measure of nutritional status, has shown significant prognostic relevance in HCC. Our research investigates the integration of the albumin-bilirubin (ALBI) grade with the GNRI to enhance prognostic stratification for patients with HCC. Utilizing data from a large nationwide registry cohort of 16,416 HCC patients, we examined the combined impact of ALBI grade and GNRI on overall survival in patients with HCC. Our findings demonstrate that incorporating ALBI grade with GNRI significantly improves risk stratification and provides a more precise prognosis, particularly in patients with preserved liver function (ALBI grade 1/2). Our results underscore the importance of integrating nutritional assessments into HCC management to enhance prognostic accuracy and optimize treatment plans.
Published Version
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