Abstract
Incoordination of gastroduodenal myoelectric activity in rabbits under immobilization stress was manifested, first, in an earlier resumption of spike activity in the duodenum than in the stomach and pyloric sphincter after its simultaneous suppression in these three parts of the gastrointestinal tract and, second, in the subsequent considerable increase of duodenal spike activity over its baseline level, while stomach and pyloric sphincter activities remained reduced. The incoordination of gastroduodenal myoelectric activity, which developed during the first hour of immobilization, was accompanied by the formation of erosive lesions in the gastric mucosa. The results of this study suggest that incoordination of gastroduodenal motor activity may be implicated in stressinduced gastric ulcers as a factor that damages the gastric mucosa by slowing down the evacuation of stomach contents and promoting duodenogastric reflux.
Published Version
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