Abstract
Objective To investigate the incidence of sleep apnea syndrome in the elderly population and its relationship with osteoporosis. Methods A total of 110 patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) in the community were included in the study. According to the apnea hypopnea index (AHI) , all patients were divided into the mild OSAHS group (n=39) , moderate OSAHS group (n=45) and severe OSAHS group (n=26). Another 45 normal subjects were included as the control group. The blood biochemical parameters (Ca2+, P3+, ALP, β-CTX) and the bone mineral density (BMD) of lumbar spine, femur and tibia in all groups were determined and compared. Pearson correlation analysis was performed for AHI and the parameters. Results There were statistically significant differences in BMI and SaO2min among the groups (P 0.05). Compared with the control group, the levels of β-CTX in the OSAHS groups significantly increased, and the content of β-CTX increased significantly with the aggravation of the disease (P<0.05). The BMD of lumbar spine, femur and tibia in the moderate and severe OSAHS groups was significantly lower than that in the control group and mild OSAHS group (P<0.05). The BMD of lumbar spine, femur and tibia significantly decreased in the severe OSAHS group compared with that in the moderate OSAHS groups (P<0.05). The Pearson correlation analysis showed that BMI and β-CTX were positively correlated with AHI (r=0.334, 0.384, P<0.05) , and SaO2min was negatively correlated with AHI (r=- 0.801, P<0.05). There was no significant correlation between Ca2 + , P3 +, ALP, BMD of lumbar spine, femur and tibia and AHI. Conclusion The incidence of OSAHS in this community is closely related to osteoporosis in the elderly population, and hypoxemia may be a risk factor for osteoporosis. Key words: Elderly population; Sleep apnea syndrome; Osteoporosis; Bone mineral density
Published Version
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