Abstract
Background/aimThyroid cancer is the most common endocrine malignancy. Recently the incidence has been increasing faster compared to other malignancies. Different studies have shown that the incidence of breast cancer in patients followed due to thyroid cancer has increased, and vice versa. The aim of this study was to evaluate the frequency of second primary cancers in the follow-up of patients with thyroid cancer.Materials and methodsIn this study, 1196 patients with thyroid cancer were evaluated in the Necmettin Erbakan University Meram Medical School’s Department of Endocrinology between 2004 and 2018. Demographic characteristics and radiological and pathological results of the patients were recorded. The presence of accompanying second malignancies in patients with thyroid cancer was investigated.ResultsIn our study, 985 (82.4%) women (mean age: 46.1 ± 13.3 years) and 211 (17.6%) men (mean age: 49.9 ± 14.2 years) were evaluated. The median follow-up was 63 months (2–164 months). Of the 1196 patients, 1126 (94.1%) had no additional cancer and 70 (5.9%) patients had a second malignancy. The accompanying second malignancies were breast cancer in 24 (2%) patients, skin cancer in 8 (0.7%) patients, renal cell cancer in 5 (0.4%) patients, lung cancer in 5 (0.4%) patients, colon cancer in 5 (0.4%) patients, lymphoma in 5 (0.4%) patients, endometrial cancer in 4 (0.3%) patients, and 14 cases of other rare types of cancer.ConclusionIn our study, it was found that the most common second primary malignancy in patients with thyroid cancer was breast cancer. However, other cancers (skin cancer, renal cell cancer, lymphoma, and colon, lung, or endometrial cancer) may occur in patients with thyroid cancer.
Highlights
Thyroid cancer is the most common endocrine malignancy
Different studies have shown that the incidence of breast cancer in patients followed due to thyroid cancer has increased and the risk of thyroid cancer has increased in the long-term follow-up of breast cancer patients
The aim of this study was to evaluate the frequency of second primary cancers in the follow-up of patients with thyroid cancer
Summary
Thyroid cancer is the most common endocrine malignancy. Thyroid cancer accounts for approximately 1.0%–1.5% of all new cancer cases [2]. It is most common in women between the ages of 30 and 70 and is 2.9 times more likely to occur in women than in men. The incidence of thyroid cancer is increasing, mortality due to thyroid cancer is decreasing. This is because of early diagnosis and effective treatment with surgery and radioactive iodine (RAI) treatment [3]. More than 90% of thyroid cancers comprise differentiated thyroid cancers, including papillary and follicular carcinoma types [4]. Less common types of thyroid cancers are medullary thyroid cancer (5%–9%) and anaplastic thyroid cancer (1%–2%) [5]
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