Incidence of Sclerosing Cholangitis Induced by Silver Nitrate in Rabbit

Abstract

Hosseini, S.V., Kumar, P.V., Bagheri, M.H., Izadpanah, A., Mohammadi, A.A., Yarmohammadi, H. and Mehrabani, D. 2005. Incidence of sclerosing cholangitis induced by silver nitrate in rabbit. J. Appl. Anim. Res., 27: 49–53. One of the most serious complications after evacuation of hydatid cyst from liver and instillation of scolicidal agents, is sclerosing cholangitis (SC), most probably caused by scholicidal agents instilled. A triple-blind randomized study was undertaken by injection of 5% hypertonic saline and 0.5% silver nitrate transhepatically into the gall bladder of two equal groups of 15 Dutch rabbits. The animals were sacrificed after four months, their livers were biopsied and cholangiography was performed. Thirty per cent of the rabbits in hypertonic saline group and 80% of silver nitrate group had developed SC. The prevalence and the severity of pathological findings of SC were significantly higher in silver nitrate group compared to hypertonic saline group. Therefore, the intra-cystic injection of 0.5% silver nitrate and 5% hypertonic saline solution should be avoided.