Abstract
BackgroundThe incidence of postoperative nausea and vomiting (PONV) is higher in patients receiving volatile anesthetics than those receiving total intravenous anesthesia (TIVA) with propofol. However, it is unclear whether its incidence is increased when a low concentration of sevoflurane is used in combination with propofol.MethodsThis prospective, randomized, controlled trial enrolled women undergoing laparoscopic gynecological surgery. Patients were randomly assigned to receive general anesthesia either with propofol alone (group P) or with 0.8% sevoflurane and propofol (group SP, n = 36, each group) for maintenance of anesthesia. The incidence of PONV and the number of patients who required antiemetics were compared.ResultsThere were no differences in the incidence of PONV and the number of patients who required antiemetics between the P and SP groups.ConclusionsA combination of 0.8% sevoflurane and propofol to maintain anesthesia does not increase the incidence of PONV compared with TIVA with propofol.Trial registrationUMIN-CTR UMIN000023647, registered 14 August 2016.
Highlights
The incidence of postoperative nausea and vomiting (PONV) is higher in patients receiving volatile anesthetics than those receiving total intravenous anesthesia (TIVA) with propofol
The coadministration of propofol with sevoflurane to maintain anesthesia has been suggested recently [9, 10] due to the antiemetic effect of propofol [11], the myocardial protective effects of sevoflurane [12, 13], and the possibility of smooth emergence from anesthesia
It has been demonstrated that the coadministration of sevoflurane and propofol to maintain anesthesia reduces the incidence of PONV compared with sevoflurane alone [14, 15]
Summary
The incidence of postoperative nausea and vomiting (PONV) is higher in patients receiving volatile anesthetics than those receiving total intravenous anesthesia (TIVA) with propofol. It is unclear whether its incidence is increased when a low concentration of sevoflurane is used in combination with propofol. Postoperative nausea and vomiting (PONV) is one of the most common adverse effects of anesthesia and is experienced by 25–30% of patients [1]. It has been demonstrated that the coadministration of sevoflurane and propofol to maintain anesthesia reduces the incidence of PONV compared with sevoflurane alone [14, 15]. The aim of this study was to compare the incidence of PONV between general anesthesia with propofol alone and propofol in combination with sevoflurane
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