Incidence of mitochondrial mutations in cohort of patients with ethambutol-induced optic neuropathy

Abstract

Background: Ethambutol-induced Optic Neuropathy (EtON) is a devastating complication of the Anti-tubercular therapy (ethambutol-based regime) which is a cornerstone for the treatment of Tuberculosis. Though the etiology of the disease is unknown yet it has been postulated to be mitochondrial associated for a long time. It is intriguing to understand the basis which will aid in recognizing the “at-risk” population. Aim and Objective: To assess the association of mitochondrial mutations in the cohort of patients with Ethambutol-induced Optic Neuropathy (EtON).