Abstract
Aim. At present, little data exist about incidence and the risk factors associated with metabolic syndrome (MetS) in patients with type 2 diabetes mellitus (T2DM). The objectives of present study were to assess the incidence and risk factors of MetS in people with T2DM. Methods. During the mean (SD) follow-up period of 11.7 (4.8) years, 3,047 patients with T2DM and free of MetS at baseline have been examined to determine incidence and predictors of progression to MetS. A modified the National Cholesterol Education Program—Adult Treatment Panel III definition with body mass index (BMI) instead of waist circumference was used for the MetS. Results. The prevalence of MetS was 63.2% (95% CI: 62.3, 64.1). The incidence of MetS was 28.5 (95% CI: 26.8, 30.2) (25.9 men and 30.9 women) per 1,000 patient-years based on 35,677 patient-years of follow-up. Multivariate analysis revealed that higher BMI and education, lower HbA1c and treatment with oral agent or insulin were associated with MetS. Conclusion. These are the first estimate of incidence and risk factors of MetS in patients with T2DM in Iran. These findings showed that the natural course of MetS is dynamic. The clinical management of patients with T2DM will contribute significantly to MetS prevention.
Highlights
Metabolic syndrome (MetS) is an important public health problem worldwide, and its prevalence is increasing [1, 2]
This is relevant in patients with type 2 diabetes mellitus (T2DM), who are at even greater cardiovascular risk [3]
The prevalence of overweight (BMI ≥ 25) was 25.1% in men, and 45.1% in women
Summary
Metabolic syndrome (MetS) is an important public health problem worldwide, and its prevalence is increasing [1, 2]. Patients with MetS are at higher risk for many long-term complications, including micro- and macro-vascular complications [2] This is relevant in patients with type 2 diabetes mellitus (T2DM), who are at even greater cardiovascular risk [3]. MetS is very common among patients with T2DM, using the Third Report of the National Cholesterol Education Program Adult Treatment Panel (NCEP/ATP III) definition; over 65% of patients with T2DM have MetS [8]. This is much higher prevalence than in comparable general populations [9, 10]. Limited information is available about the incidence of the MetS and its risk factors in patients with T2DM and none in Iran
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
