Incidence of levodopa-induced dyskinesia in ederly patients with Parkinson's disease and related factors

Abstract

One hundred patients with Parkinson's disease (PD) aged 60 and above treated with levodopa were enrolled in this cross section study. The general conditions, medication, unified Parkinson's disease rating scale (UPDRS) scores and the incidence of levodopa-induced dyskinesia (LID) were documented. The incidence rate of LID in this group of PD patients was 37.0% (37/100). The incidence was significantly higher in patients with levodopa treatment ≥4 years than that in patients with levodopa treatment <4 years(55% vs. 26%, χ2=8.770, P=0.003). The incidence rate ofpeak dosagedyskinesia in tremor-dominant PD patients was lower than that in rigidity-dominant PD patients(χ2=4.399, P=0.036). The incidence rate of LID was correlated with the duration of levodopa therapy. Amantadine may reduce the incidence ofoffdystonia. Key words: Dyskinesia, drug-induced; Parkinson disease; Levodopa