Incidence of hyperuricemia among the fishermen in the Jiaodong region and its relationship with the coronary heart disease

Abstract

Objective To investigate the incidence of hyperuricemia among the fishermen in the Jiaodong region its relationship with the coronary heart disease (CHD).Methods A population survey of height and weight was made in 132 fishermen and 156 patients undergoing coronary angiography,at the same time,blood uric acid,blood sugar,cholesterol,triglycerides,as well as high/low density lipoprotein (HDL/LDL) were also determined in them.In accordance with the survey results,the fishermen were divided into the CHD group and the control group.Results The level of blood uric acid in the fishermen on the average was (377.3 ± 79.8) μmol/L,while the level of blood uric acid in the other population group was on the average (356.8 ± 70.1) μmol/L.Statistical significance could be seen,when comparisons were made between them (P ＜ 0.01).Lipid metabolism in the fishermen with high uric acid was abnormal,and rates of obesity and diabetes were also significantly higher than those of the fishermen with normal uric acid.Logistic regression analysis showed that obesity,alcoholism,blood lipid disorder were risk factors of hyperuricemia.Of all the patients,blood uric acid levels of heavy and moderate alcohol drinkers were all significantly higher than those of other patients,with statistical significance (P ＜0.01).In 132 fishermen,blood uric acid level in the coronary heart disease group was significantly higher than that of the control group (P ＜ 0.01).Single factor analysis indicated that hyperuricemia was a risk factor involved in the occurrence of CHD in fishermen(OR =2.022,95％ CI:1.098-3.723,Wald x2 =5.153,P =0.023).Conclusions Fishermen had a higher incidence of hyperuricemia than other population groups,and high blood uric acid was an influencing factor for the occurrence of coronary heart disease.For this reason,efforts should be made on the prevention and treatment of hyperuricemia in fishermen. Key words: Fishermen; Hyperuricemia; Coronary heart disease