Abstract

The incidence and severity of heterotopic ossification (HO) in two homogeneous groups of patients that received surface replacement arthroplasty (SRA) and conventional total hip arthroplasty (THA) were evaluated retrospectively. Thirty-nine patients undergoing 42 hip resurfacing procedures and 41 primary cementless THAs through an anterolateral approach received a 10-day course of 150 mg/die of indomethacin postoperatively. The median surgical time was 190 minutes and 156 minutes, respectively (P < 0.003). At a minimum 1-year followup, the development of HO was assessed on standard X-ray using Brooker grading. Ectopic bone formation was detected in five cases (11.9%, two Brooker grade I and three grade II) in the SRA group and in 14 hips (34.1%, 12 grade I and two grade II) treated with conventional THA, but the difference was not significant (P < 0.11). No clinically relevant periprosthetic ossification (Brooker III or IV) occurred in both groups. Although the difference was not statistically significant, the incidence of HO after SRA was lower than conventional THA. More extensive soft tissue trauma, bone debris, and longer operative time in hip resurfacing are not likely to be absolute risk factors for HO. Further investigations including larger patient populations are needed to confirm these findings.

Highlights

  • Heterotopic ossification (HO) consists of an abnormal bone formation in soft tissue, which is typically observed following total hip arthroplasty (THA).The overall incidence of periprosthetic ossifications has been reported ranging from 5% to 90% [1], though the rate of clinically relevant heterotopic ossification (HO) (Brooker grades III and IV) that could be associated with impaired range of motion (ROM) and decreased functional outcome is 9% [2].The pathophysiology of HO is multifactorial, and wellknown predisposing factors in THA are male gender, hypertrophic osteoarthritis, ankylosing spondylitis, and diffuse idiopathic skeletal hyperostosis

  • Ectopic bone formation was detected in five cases (11.9%, two Brooker grade I and three grade II) in the surface replacement arthroplasty (SRA) group and in 14 hips (34.1%, 12 grade I and two grade II) treated with conventional THA, but the difference was not significant (P < 0.11)

  • The overall incidence of periprosthetic ossifications has been reported ranging from 5% to 90% [1], though the rate of clinically relevant HO (Brooker grades III and IV) that could be associated with impaired range of motion (ROM) and decreased functional outcome is 9% [2]

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Summary

Introduction

Heterotopic ossification (HO) consists of an abnormal bone formation in soft tissue, which is typically observed following total hip arthroplasty (THA).The overall incidence of periprosthetic ossifications has been reported ranging from 5% to 90% [1], though the rate of clinically relevant HO (Brooker grades III and IV) that could be associated with impaired range of motion (ROM) and decreased functional outcome is 9% [2].The pathophysiology of HO is multifactorial, and wellknown predisposing factors in THA are male gender, hypertrophic osteoarthritis, ankylosing spondylitis, and diffuse idiopathic skeletal hyperostosis. Heterotopic ossification (HO) consists of an abnormal bone formation in soft tissue, which is typically observed following total hip arthroplasty (THA). Due to a wider exposure and bone debris from femoral head reaming, higher rates of overall (range, 26% to 58.3%) and severe (range, 4% to 7.6%) HO after surface replacement arthroplasty (SRA) have been reported [1, 4, 5]. At a minimum 1-year followup, Rama et al [6] found an increased incidence and severity of ectopic bone formation in SRA compared to conventional THA, hypothesizing the need to routinely adopt preventive measures after hip resurfacing procedures. In a recent meta-analysis study, a significantly higher presence of HO was detected in resurfaced hips [7]

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