Abstract

Heterotopic ossification (HO) may cause pain, and can lead to loss of hip motion after total hip arthroplasty (THA). There is evidence that pulsed lavage may lower the incidence of HO formation. We assessed the effect of pulsed lavage on the incidence of HO in 87 male patients after THA. All patients received an uncemented THA through a posterolateral approach. 39 patients were treated with pulsed lavage (index group) and 48 males were treated without pulsed lavage (historical control group, matched on aetiology, gender, surgical approach and type of prosthesis). Both groups followed the same postoperative treatment regimen. HO severity was scored in both groups according to the Brooker classification by three blinded orthopaedic surgeons one year postoperatively. Good inter-observer agreement (Kappa 0.7) for scoring HO was found. The incidence of HO (51%) in the index group did not differ significantly (p = 0.53) from the control group (58%). However, the incidence of clinically relevant HO (Brooker grades 3 and 4) was significantly lower (p = 0.04) in the index group (3%) as compared to the control group (17%). These results suggest a beneficial effect of pulsed lavage on the incidence of severe heterotopic ossification after cementless THA in male patients.

Highlights

  • Heterotopic ossification (HO) is a well-known complication after total hip arthroplasty (THA)

  • All patients received an uncemented THA through a posterolateral approach. 39 patients were treated with pulsed lavage and 48 males were treated without pulsed lavage

  • Our results demonstrated significantly less severe HO formation (Brooker grades 3 and 4) with the use of pulsed lavage in male patients treated for symptomatic primary hypertrophic coxarthrosis with uncemented THA

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Summary

Introduction

Heterotopic ossification (HO) is a well-known complication after total hip arthroplasty (THA). The incidence of HO varies from 8% to 90% depending on risk factors and the criteria used [1,2]. A large meta-analysis of 13 randomized trials, involving 4129 individuals treated with Non Steroid Anti Inflammatory Drugs (NSA IDs) after major hip surgery, reported an overall HO incidence of 37% [3]. Advanced stages of HO, Brooker grades 3 and 4, are clinically relevant because of pain and hip function impairment [4,5,6]. Some have suggested that surgical trauma may stimulate primitive mesenchymal cells to differentiate into osteoblastic cells, which form bone [7,8]. It seems likely that HO is the result of inappropriate differentiation of pluripotential mesenchymal cells into osteoblastic stem cells

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