Incidence of Cholangiocarcinoma in Patients with History of Colorectal Cancer. Multicenter Experience

Abstract

Introduction: Cholangiocarcinoma (CCA) represents one the most common primary malignancy of the liver. Cirrhosis, HCV infection, Cholestatic diseases represent well known predisposing factors. Late diagnosis of CAA is associated with a poor prognosis. History of colorectal cancer (CRC) is supposed to be a risk factor. Method: Data were retrospectively collected from two different HPB surgical centers in Italy (Ancona, Roma-Gemelli) to identify all patients with CCA and CRC between January 2000 to December 2018. All the data from patient history, surgical and oncological treatments were examinated. Histopatological examination of both CCA and CRC characteristics were analised. Genetics characteristics of both tumours were collected. Results: A total of 26 patients developed biopsy-proven CCA after CRC. The median time between CRC and CCA diagnosis was 111,7 months. All the CRC were successfully treated with surgery and 5 patients underwent adjuvant chemotherapy. Median age at the CCA diagnosis was 66,8 years. 23 (88,4%) patients underwent R0 surgical treament. 3 patients underwent palliative treatments. After a median followup of 73,4 months, 5 years survival was 61,5%. Conclusions: To our knowledge, this is the largest series of patients with CCA and CRC. Treatment can allow a significant 5 year survival. It is also mandatory a follow up for CAA in CRC patients.