Abstract
Introduction: The global burden of bacterial skin infection is substantial. We aimed to determine the common pathogens causes skin infections and their antimicrobial resistance pattern. Methods: A retrospective record review of data claimed from the microbiology department at Ber-Ustta Milad skin hospital between Jan 2009 to December 2018 was conducted. The consequence of interest was the antimicrobial sensitivity of bacterial isolates. Chi square was used for statistical analysis. Results: Out of 1,141 collected samples, a total of 455 isolates of different medically-significant bacteria were analyzed. The most common pathogen was S. aureus (97.14%), followed by E. coli (93.71%), and the least common was Shigella (0.57%). From the various inoculated samples, S. aureus and proteus were highly resistant to penicillin (34.3%, 75% respectively) and ampicillin (28.6%, 62.5% respectively). E. coli was highly resistant to ampicillin (45.12%) and penicillin (35.96%), whereas the lowest resistant was against imipenem (3.05%). While, Pseudomonas was highly resistant to ampicillin and augmentin (62.5%), whereas the lowest resistance rate was marked to erythromycin, sulfamethoxazole and imipenem (25%). Ciprofloxacin, gentamicin and nalidixic acid were the only sensitive agents. Conclusions: There is a high burden of bacterial resistance to common antibiotics in our population samples. Recognition of the potential resistant strains of pathogen causing skin infection can help in guiding proper choice of antibiotic therapy.
Highlights
The global burden of bacterial skin infection is substantial
Given the paucity of population-based studies of bacterial skin infection in Libya, with and without cultures, we conducted this study with the aim of determining the common causative bacteria of skin infection and their antibiotic resistance pattern among patients attending specialist skin hospital in Tripoli city of Libya
This is a retrospective investigation of bacterial skin infections and antibiotic resistance for samples taken from a total of 1,141 patients confirmed with bacterial skin infection and admitted to Ber Al-Ustta Milad hospital in Tripoli city over a period of 10 years from Jan 2009 to December 2018
Summary
We aimed to determine the common pathogens causes skin infections and their antimicrobial resistance pattern. Skin infections are a worldwide significant clinical concern characterized by microbial attack of the skin layers and underlying soft tissues [1] The incidence of these infections may differ from one area to another, ranging from mild to life-threatening condition [2]. A report of culture-confirmed skin infection in the United States revealed that the most causative organism is S. aureus, Enterococcus spp., Pseudomonas aeruginosa, Escherichia coli Given the paucity of population-based studies of bacterial skin infection in Libya, with and without cultures, we conducted this study with the aim of determining the common causative bacteria of skin infection and their antibiotic resistance pattern among patients attending specialist skin hospital in Tripoli city of Libya
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