Incidence and risk factors of postoperative cognitive dysfunction after non-cardiac surgery in children and juvenile

Abstract

Objective To investigate the incidence and risk factors of postoperative cognitive dysfunction (POCD) in children and juvenile after non-cardiac surgery.Methods 1 10 patients undergoing elective non-cardiac surgery aged between 4 y16 y,ASA Ⅰ-Ⅱ,were collected as operation group,and 50 healthy age-matched children were collected as control group.Children's childbirth,education,history of operation with anesthesia,and complication of surgical patients were recorded.Neuropsychological tests (wechsler preschool and primary scale of intelligence or wechsler intelligence scale for children-revised) were completed 1 d before and 3 d after surgery.POCD was calculated as a combined Z-score.Multivariate logistic regression analyses were used to identify independent risk factors of POCD.Results 100 in operation group and 43 in control group completed the study.POCD was confirmed in 15/100 (15.0％) in operation group compared with 1/43 (2.3％) in control group 3 d after surgery.Logistic regression analysis revealed that the history of operation and postoperative infection were independent risk factors of POCD.Conclusions The occurrence rate of POCD after non-cardiac surgery in children and juvenile is 15.0％.Children and juvenile who had some exposure to operation before and postoperative infection are more prone to develop POCD. Key words: Children ; Juvenile; Surgical history ; Cognitive function; Risk factors