Abstract
Objective: To assess the incidence and risk factors of hyperuricemia among Chinese adults in 2017–2018. Methods: A total of 2,015,847 adults (mean age 41.2 ± 12.7, 53.1% men) with serum uric acid concentrations assayed on at least two separate days in routine health examinations during 2017–2018 were analyzed. Hyperuricemia was defined as fasting serum urate concentration >420 μmol/L in men and >360 μmol/L in women. The overall and sex-specific incidence rate were stratified according to age, urban population size, geographical region, annual average temperature and certain diseases. Logistic regression analyses were performed to explore risk factors associated with hyperuricemia. Results: 225,240 adults were newly diagnosed with hyperuricemia. The age- and sex-standardized incidence rate per 100 person-years was 11.1 (95%CI: 11.0–11.1) (15.2 for men and 6.80 for women). The risk of hyperuricemia was positively associated with younger age, being male, larger urban population size, higher annual temperature, higher body mass index, lower estimate glomerular filtration rate, hypertension, dyslipidemia and fat liver. Conclusions: The incidence of hyperuricemia was substantial and exhibited a rising trend among younger adults, especially among men. Socioeconomic and geographic variation in incidence were observed. The risk of hyperuricemia was associated with estimate glomerular filtration rate, fat liver and metabolic factors.
Highlights
IntroductionChina [1,2,3]. In the United States, it increased from 18.2% in 1988–1994 [1] to 21.4% in
The prevalence of hyperuricemia has been increasing worldwide, includingChina [1,2,3]
Accumulating evidence suggests that people with hyperuricemia may have a higher future risk of gout [7], chronic kidney disease [8], hypertension [9], cardiovascular disease [10,11], and mortality [12], via mechanisms such as monosodium urate crystal deposition [13,14], endothelial dysfunction [15,16], intracellular and mitochondrial oxidative stress [17] and stimulation of the intracellular renin angiotensin system, etc. [18], which could pose a serious problem for public health
Summary
China [1,2,3]. In the United States, it increased from 18.2% in 1988–1994 [1] to 21.4% in. In China, it increased from 1.4% to 9.9% for men and. Hyperuricemia has already become one of the most common metabolic diseases in China [6]. Given the rapidly increasing prevalence and accompanied serious health threats, the epidemiology of hyperuricemia has not been given special attention it de-. Res. Public Health 2021, 18, 2360 serves [6]. Nationwide Chinese data on the epidemiological of hyperuricemia is still limited, especially about the incidence. An increasing number of the Chinese population have visited health examination centers, which provides an unique opportunity to understand the status of hyperuricemia in China. We estimated the incidence of hyperuricemia based on the health examination data of 2,015,847 Chinese adults from 30 provinces, who attended health examinations during 2017–2018
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