Abstract
We investigated the incidence and extent of Lewy body (LB)‐related α synucleinopathy (LBAS) in the olfactory bulb (OB) in 320 consecutive autopsy cases from a general geriatric hospital (81.5±8.5‐years old). Paraffin sections were immunostained with anti‐phosphorylated α‐synuclein (psyn#64), tyrosine hydroxylase (TH), phosphorylated tau (AT8) and Aβ antibodies. Out of 102 LBAS cases (31.9%), OBs were involved in 85 cases (26.6%). Among them 14 were affected in the secondary olfactory structure (mitral, tufted, granule, and periglomerular cells and the surrounding neuropils) alone, 2 in the tertiary olfactory structure (anterior olfactory nucleus) and 69 in both. In five cases, intracytoplasmic aggregates were found exclusively in OB and three of the five accompanied Alzheimer disease (Braak NFT stage ≥IV and SP stage C). Only a few TH‐immunoreactive periglomerular cells presented LBAS. Thirty five LBAS cases with loss of pigmentation in substantia nigra all showed LBAS in OB. No correlation was found between LBAS and tauopathy or Aβ amyloidosis in OB, but AD changes significantly promoted LBAS in OB. This study demonstrated high incidence and extension from the second to tertiary olfactory structure of LBAS in human OB with aging.
Published Version
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