Abstract
This report presents data on the rates of inactivation of 4 adipokinetic hypophysial peptides by adipose and extraadipose tissues of the rat and rabbit, and correlates these data with the in vitro and in vivo adipokinetic potencies of the peptides in these 2 species. The peptides under study (adrenocorticotropin, β-melanocyte-stimulating hormone, vasopressin and pituitary fraction H) were incubated for 1 hr with various tissue homogenates, and the adipokinetic activity remaining in the incubation mixture was then determined by introducing slices of rabbit, guinea pig, hamster or rat adipose tissue. The data showed: 1) Eight tissues of the rat (kidney, liver, adrenal, adipose tissue, lung, heart, testis and spleen) inactivate one or more of the peptides. 2) Ratios of the rates of inactivation of the 4 peptides vary markedly from one organ to another, and indicate the presence of at least 3 different inactivating enzymes in the rat. 3) While rat adipose tissue inactivates all 4 peptides under study, rabbit ...
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