Abstract
There are two steps in the process of inactivation of antitumor antibiotics upon in vitro contact with Ehrlich ascites tumor cells or mouse liver homogenate: (1) adsorption of antibotics to the cell or cell homogenate, this occuring rapidly even in the cold, and (2) a temperature-dependent inactivation, which proceeds gradually. Ayamycin A2, chromomycin A3 and actinomycin D were strongly adsorbed to Ehrlich tumor cells and to the liver homogenate, but mitomycin C and penicillin G were not. The temperature-dependent inactivation was most marked with ayamycin A2, chromoycin A3 and mitomycin C, but only slight or none with actinomycin D, chloramphenicol and penicillin G. Upon contact with rabbit red blood cells or sera, these inactivations were not marked except for the case of ayamycin A2.
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