Abstract
Aim Dermatophytosis is one of the main fungal diseases in humans and animals all over the world. Galla chinensis, a traditional medicine, has various pharmacological effects. The goal of this study was to evaluate the treatment effect of Galla chinensis solution (GCS) on dermatophytosis-infected dogs (Microsporum canis, Microsporum gypseum, and Trichophyton mentagrophytes, resp.). Methods The treatment effects of GCS were evaluated by mycological cure rates and clinical score comprised of three indices, including inflammation, hair loss, and lesion scale. Results The results showed that, in the three models of dermatophytosis, GCS significantly (P < 0.05) improved skin lesions and fungal eradication. GCS (10% and 5%) had higher efficacy compared to the positive control (Tujingpi Tincture). The fungal eradication efficacy exceeds 85% after treatment with GCS (10%, 5%, and 2.5%) on day 14. Conclusion The GCS has antidermatophytosis effect in dogs, which may be a candidate drug for the treatment of dermatophytosis.
Highlights
Dermatophytosis is one of the main fungal diseases of humans and animals all over the world, and the major cause is associated with fungal infection, such as genera Microsporum, Trichophyton, and Epidermophyton [1, 2]
The damage of control group has been reduced after treatment for 7 days, the lesion was still obvious through 14day treatment
Dermatophytosis is mainly caused by Trichophyton rubrum, M. canis, M. gypseum, and T. mentagrophytes, which usually invades keratinized structure and infects the skin, hair, and nails of animals [2]
Summary
Dermatophytosis is one of the main fungal diseases of humans and animals all over the world, and the major cause is associated with fungal infection, such as genera Microsporum, Trichophyton, and Epidermophyton [1, 2]. This disease is characterized mainly by invading keratinized tissues, such as hair, skin, and nails, and producing multifocal alopecia, scaling, and circular lesions. It is often painful and has a negative influence on the appearance of animals [3]. It is urgent to develop new drugs for treatment of dermatophytosis
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