Abstract
GENERAL COMMENTARY article Front. Neuroinform., 17 May 2012 https://doi.org/10.3389/fninf.2012.00019
Highlights
The use of high-resolution MRI for the evaluation of structural changes in the mouse brain is rapidly gaining favor with researchers
In vivo imaging allows for the longitudinal analysis of structural change, a benefit that can not be underestimated
Longitudinal studies lend themselves to other forms of statistical analysis, such as repeated measures ANOVAs, which can increase the statistical power of the studies
Summary
The use of high-resolution MRI for the evaluation of structural changes in the mouse brain is rapidly gaining favor with researchers. The tradeoff between in vivo vs ex vivo MR brain imaging in the mouse” presented by Lerch et al (2012), this is exactly what is considered. Ex vivo imaging benefits from greater resolution and sensitivity due to the lack of constraints on imaging time, the use of tighter fitting coils, high concentration contrast agents, and a lack of movement artifacts.
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