Abstract
: We present the first three-dimensional (3D) data sets recorded using optical coherence elastography (OCE). Uni-axial strain rate was measured on human skin in vivo using a spectral-domain optical coherence tomography (OCT) system providing >450 times higher line rate than previously reported for in vivo OCE imaging. Mechanical excitation was applied at a frequency of 125 Hz using a ring actuator sample arm with, for the first time in OCE measurements, a controlled static preload. We performed 3D-OCE, processed in 2D and displayed in 3D, on normal and hydrated skin and observed a more elastic response of the stratum corneum in the hydrated case.
Highlights
It is well known that pathological tissue is often stiffer than healthy tissue [1]
Initial elastography techniques used ultrasound [4] and magnetic resonance imaging (MRI) [5] as the underlying imaging modalities and in vivo elastography has been proposed for clinical applications in the diagnosis of breast cancer [6,7], prostate cancer [8], cirrhosis of the liver [9], brain tumors [10] and atherosclerosis [11]
An audio-frequency sub-micron excitation technique has been reported, which overcame the need to allow strain dissipation [19,20]. It was demonstrated on human skin using a TD-optical coherence tomography (OCT) system, and the line rate was limited to ~1 Hz
Summary
It is well known that pathological tissue is often stiffer than healthy tissue [1]. Much research has focused on using the elastic properties of tissue as a contrast mechanism to form images, a technique known as elastography [2,3]. An audio-frequency sub-micron excitation technique has been reported, which overcame the need to allow strain dissipation [19,20]. It was demonstrated on human skin using a TD-OCT system, and the line rate was limited to ~1 Hz. It was demonstrated on human skin using a TD-OCT system, and the line rate was limited to ~1 Hz Such long acquisition times are impractical for in vivo imaging in a clinical setting and result in large motion artifacts
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