Abstract
PurposeThe purpose of this study was to compare the surface dose of 7-field IMRT (7 F-IMRT), tangential beam IMRT (TB-IMRT), and tangential beam 3D-CRT (3D-CRT) of breast cancer patients receiving adjuvant radiotherapy by means of in vivo GafChromic film dosimetry.Material and methodsBreast cancer patients receiving adjuvant radiotherapy of the whole breast or the chest wall were eligible for the study. Study patients were treated with a treatment plan using two different radiotherapy techniques (first patient series, 3D-CRT followed by TB-IMRT; second patient series, TB-IMRT followed by 7 F-IMRT). The surface dose was evaluated on three consecutive treatment fractions per radiotherapy technique using in vivo GafChromic film dosimetry. The paired t-test was used to assess the difference of in vivo GafChromic film readings or calculated plan parameters of the compared pairs of radiation techniques for statistical significance.ResultsForty-five unselected breast cancer patients were analysed in this study. 7 F-IMRT significantly reduced the surface dose compared to TB-IMRT. Differences were greatest in the central and lateral breast or chest wall region and amounted to a dose reduction of -11.8% to -18.8%. No significant difference of the surface dose was observed between TB-IMRT and 3D-CRT. A corresponding observation was obtained for the calculated skin dose derived from dose-volume histograms.ConclusionsIn adjuvant breast cancer radiotherapy, 7 F-IMRT offers a significantly reduced surface dose compared to TB-IMRT or 3D-CRT.
Highlights
Breast cancer is the most common cancer in females worldwide [1]
In adjuvant breast cancer radiotherapy, 7 F-Intensity modulated radiotherapy (IMRT) offers a significantly reduced surface dose compared to tangential beam IMRT (TB-IMRT) or 3D-conformal radiotherapy (3D-CRT)
In vivo GafChromic film dosimetry measurements and calculated plan parameters comparing two radiotherapy techniques in the same patient were obtained of 45 unselected breast cancer patients (Table 1)
Summary
The majority of the patients will receive adjuvant radiotherapy after breast cancer surgery. The adjuvant radiotherapy after breast conserving surgery as well as the adjuvant radiotherapy after mastectomy of high risk patients have been shown to significantly improve local control and long-term survival [2,3]. Breast cancer radiotherapy is associated with acute and late radiation effects most importantly of the skin, The purpose of this study was to compare the surface dose of 7-field IMRT (7 F-IMRT), tangential beam IMRT (TB-IMRT), and tangential beam 3D-conformal radiotherapy (3D-CRT) of breast cancer patients after breast conserving surgery or mastectomy by means of in vivo RT technique 1 In vivo FD. Patient series 2: TB-IMRT versus 7 F-IMRT
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