Abstract
The oxidative stress induced by excessive synthesis of Reactive Oxygen Species (ROS) or reduced antioxidant synthesis, is involved in physi ological processes (normal pregnancy) or pathologic al processes, some of them with a great echo in the fi eld of medical practice. For this reason, there are deeply justified the more frequent attempts to use in prac tice the compounds with antioxidant potential in th e prophylaxis and treatment of some diseases which in volve oxidative stress. The authors have studied th e alterations of the oxidative stress parameters, ass essed by the measuring of serum lipid peroxides, in the same time with the total antioxidant capacity- hydrogen donors, in Wistar female rats during gestation. The determinations were made in the 21st day and they were compared with the ones of a group of animals which have received during pregnancy- week 1, week 2, week 3- by gavages one dose of Chitosan (0,5 mg/animal/dose), a product known for its antioxidan t capacity, and of a group of animals which receive d during pregnancy-week 1, week 2, week 3- one dose of Vitamin C (100 mg/animal/dose). After the results were analysed, it was concluded that during gestation th ere appears a significant increase of lipid peroxid ation, but also of the antioxidant systems at the end of gesta tion, which confirms the involvement of oxidant/ an tioxidant systems in normal pregnancy. In animals which received Chitosan during gestation or Vitamin C, respect ively, there was a decrease of the oxidative stress parame ters.
Published Version
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