Abstract
The objective of this work was to study the photoacoustic effect of a special nanoparticle for selective cancer cell killing both in vitro and in vivo. The nanoparticles (NPs) consisting of indocyanine green (ICG), phospholipid-polyethylene glycol (PL-PEG) and folic acid (FA) were used as cancer-targeting nanoprobes. Cancer cells incubated with the ICG-PL-PEG-FA solution were exposed to laser pulses. Finally, tumors in mice were treated with photoacoustic technique. High selectivity of the photoacoustic destruction of cancer cells was observed. The tumors in mice after photoacoustic treatment showed a much slower growth rate. The destruction of the cells was due to the photoacoustic effect originating from the NPs. The ICG-PL-PEG NP-based photoacoustic therapy would be a safe and highly efficient cancer treatment technique.
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