In vivo mucoadhesive strength appraisal of gum Manilkara zapota

Singh Sudarshan,Bothara Sunil B

doi:10.1590/s1984-82502015000300021

Singh Sudarshan, Bothara Sunil B

Open Access

https://doi.org/10.1590/s1984-82502015000300021

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Abstract

The mucilage (MMZ) extracted from the seeds of Manilkara zapota(Linn.) P. Royen syn. using maceration techniques was evaluated for mucoadhesive strength by various in vitro and in vivo methods. The result showed that mucoadhesive strength of seeds mucilage have comparable property toward natural and synthetic polymers such as Guar Gum and hydroxyl propyl methyl cellulose (HPMC E5LV) under the experimental conditions used in this study. Briefly, it could be concluded that the seed mucilage of Manilkara zapota can be used as a pharmaceutical excipient in oral mucoadhesive drug delivery systems. Further, it may be appropriate to study the changes in these properties after chemical modifications.

Highlights

IntroductionHigh-molecularweight (approximately 200,000), polyuronides consisting of sugar and uronic acid units (Trease, Evans, 2002)
Mucilages are naturally occurring, high-molecularweight, polyuronides consisting of sugar and uronic acid units (Trease, Evans, 2002)
Present study describes characterization of mucilage isolated from the seeds of Manilkara zapota as a mucoadhesive agent after evaluating it by various reported methods such as shear stress measurement, Wihelmy’s method, detachment force measurement, recording of adherence, falling sphere method, rotating cylinder method, falling liquid film technique, ex-vivo residence time, in-vitro wash off test, and in vivo mucoadhesive strength

Summary

Introduction

High-molecularweight (approximately 200,000), polyuronides consisting of sugar and uronic acid units (Trease, Evans, 2002). These are esters of sulphuric acid, wherein ester group is a polysaccharide complex (Kokate, Purohit, Gokhale, 2005). Mucilages resemble gums and pectins but differ in their physical properties. Gums are considered to be pathological products formed upon injury of the plant or owing to unfavorable conditions such as drought, by a breakdown of cell walls (extracellular). On the other hand mucilage is regarded as normal physiological product of metabolism formed within the cell or deposited on it in layers. Among the richest sources of mucilage are cacti (and other succulents), and flax seeds

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