Abstract
This study demonstrated the feasibility of using hyperpolarized 13C-MR spectroscopic imaging with [1-13C]-pyruvate to evaluate in vivo spinal cord metabolism. High pyruvate and relatively small lactate signal were observed in the cervical spinal cords of naive rats. Lactate and pyruvate measures were similar for spinal cord and supratentorial brain. The results from this study establish baseline measures for spinal cord hyperpolarized MRS imaging with 13C pyruvate. This technique holds promise as a valuable molecular imaging tool for monitoring biochemical processes in the normal and diseased spinal cord.
Highlights
ObjectivesThe purpose of this study was to explore the feasibility of using hyperpolarized 13C-MRSI with [1-13C]-pyruvate for evaluating in vivo metabolism of the spinal cord in rodents and establish baseline spectroscopic measures in the spinal cord relative to brain
The spine at C4 –C5 was placed at the center of the radiofrequency coil so that both the spine at C4 –C5 position and the supratentorial brain were located within the 7-cm effective region of the coil
The period of 18 –35 seconds after injection was used as an imaging window for subsequent 13C 3D-MRSI studies
Summary
The purpose of this study was to explore the feasibility of using hyperpolarized 13C-MRSI with [1-13C]-pyruvate for evaluating in vivo metabolism of the spinal cord in rodents and establish baseline spectroscopic measures in the spinal cord relative to brain
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