Abstract
In an attempt to explain the sensitivity of the brain to methylmercury, investigators have monitored various biochemical parameters in systems poisoned with this compound. YOSHINO et al. (1966) measured changes in brain cortex slices from rats severely intoxicated with methylmercury. Although several alterations were observed in animals showing neurological symptoms, only protein synthesis decreased during both the latent period and after the onset of symptoms. It has recently been observed that in vivo brain protein synthesis tended to decrease in rats mildly intoxicated with methylmercury. No investigations have been reported concerning the effects of low or extremely high doses of methylmercury on in vivo protein synthesis. We, therefore, measured in vivo /sup 14/C-leucine incorporation into brain protein in 48 hour old rats which received low levels of the mercurial during the fetal stage, and also in severely poisoned adult female rats showing neurological symptoms.
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