Abstract
Vitamin C (ascorbic acid) is a water-soluble vitamin and essential for collagen, carnitine and neurotransmitter biosynthesis. Naproxen sodium is propionic acid derivative and anti-inflammatory non-steroid agent. The aim of the study was to assess genotoxicity of selected medicaments and their possible effects on genetic material using Allium bioassay. The treatment of onion bulbs with fresh solutions of Naproxen Sodium (Nalgesin S®) and Vitamin C was performed using selected concentrations (550, 825 µg/ml and 250, 500, 1000 µg/ml respectively) in 72 hours time period. Control group was also set up.The microscopic parameters (mitotic index and chromosomal aberrations) of Allium root tips as well as the frequency of aberrant mitotic phases were analyzed. Both medicaments (vitamin C and Naproxen Sodium) caused increased frequency of abnormal mitosis when compared to control group.
Highlights
Plant bioassays are well-established test systems used for screening and monitoring of chemical substances with mutagenic and carcinogenic potential
The present study was designed to examine the effect of Vitamin C and Naproxen Sodium (Nalgesin S®) on cell divisions in the root meristems of Allium cepa, to reveal the genotoxic effect and chromosomal abnormalities induced by selected medicaments
L-ascorbic acid is a co-factor for monooxigenase and hydroxylase enzymes involved in the synthesis of collagen, carnitine and neurotransmitters (Naidu, 2003)
Summary
Plant bioassays are well-established test systems used for screening and monitoring of chemical substances with mutagenic and carcinogenic potential. Using plant bioassays for testing and monitoring have several advantages such as: they are easy to handle, inexpensive and in many cases more sensitive that other available systems (Maluszynska et al 2005). The A. cepa bioassay is important since it is an excellent model in vivo, where the roots grow in direct contact with the substance of interest (Pastori et al 2013). Correlation studies regarding the sensitivity of the A. cepa bioassay and other systems are important for the evaluation of the environmental risk and the obtained data can be extrapolated to other organisms, including humans (Leme et al 2009, Pastori et al 2013).
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