Abstract
Nanostructure lipid carriers (NLCs) were developed for the delivery of curmumin (CRN), a potent anticancer agent with low bioavailability, for the treatment of prostate cancer. NLCs prepared using high pressure homogenization (HPH) with around 150 nm particle size, − 40 V ζ-potential and excellent long-term stability. Cellular uptake of CRN-SLN showed nanoparticle localization in the cytoplasm around the nucleus. CRN-NLCs were assessed using flow cytometry and found to cause early and late apoptotic events at 100 μg/ml CRN concentrations. CRN-NLC nanoparticles were administrated to nude mice with LNCaP prostate cancer xenografts and demonstrated substantial tumour volume suppression (40%) with no weight loss compared to pure CRN (ethanolic solution). Overall, NLCs were proved a suitable carrier for passive drug delivery and cancer treatment.Graphical abstract
Highlights
Nanostructured lipid carriers (NLCs) are versatile drug delivery systems that have been employed for the delivery of drug substances with enhanced clinical efficacy
We developed curcumin-loaded NLCs for the treatment of prostate cancer
All materials used for the NLCs including the lipids, surfactant and oily phase were generally recognised as safe (GRAS)
Summary
Nanostructured lipid carriers (NLCs) are versatile drug delivery systems that have been employed for the delivery of drug substances with enhanced clinical efficacy. Their wide applicability lies on the unique features they present such as increased drug encapsulations, long term physical and chemical stability of the encapsulated drug, surface functionalization and site-specific targeting [1, 2]. They can be produced using high pressure homogenization (HPH) under aseptic conditions while scale-up can be performed in a batch or continuous mode reaching a capacity of 100–150 kg/h. The developed NLC formulations showed an increase of 16.8fold in AUC and 40-fold of Cmax when compared to a commercial suspension
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