Abstract
In vivo effects of sodium fluoride on rat serum protein components and selected serum enzymes were examined by starch gel electrophoresis. Fluoride, at levels of 3, 10, or 100 p.p.m., was administered in drinking water for 26, 38 or 50 days after weaning. Eight protein components were detected after electrophoresis; eight esterase, one aminopeptidase and one alkaline phosphatase components were observed. After 26 days NaF, component mobilities were significantly higher than in control sera but by the longest exposure time, 50 days, were significantly less than in controls. Enzyme activities and the amount of protein (represented by staining intensity) were decreased more by fluoride administration than were mobilities. Enzyme inhibition paralleled magnesium ion requirement; alkaline phosphatase was most inhibited, esterase components were selectively inhibited, aminopeptidase was unaffected. Effects on certain components showed a dose and/or duration relationship. An enzyme hypothesis for the prophylactic properties of fluoride is supported by these data.
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